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<DIV>En esta direccion he encontrado lo que sigue, no pone mucho pero algo es
algo. Se refiere a todas las estatinas</DIV>
<DIV> </DIV>
<DIV><FONT face=Arial size=2>Luis Salar</FONT></DIV>
<DIV><FONT face=Arial size=2>Valencia</FONT></DIV>
<DIV><FONT face=Arial size=2></FONT> </DIV>
<DIV><STRONG><A
href="http://www.medscape.com/druginfo/SideEffect?id=1-6312&name=SIMVASTATIN+ORAL&DrugType=1&MenuID=ADE&ClassID=N&GeneralStatement=Y">http://www.medscape.com/druginfo/SideEffect?id=1-6312&name=SIMVASTATIN+ORAL&DrugType=1&MenuID=ADE&ClassID=N&GeneralStatement=Y</A></STRONG></DIV>
<DIV><STRONG></STRONG> </DIV>
<DIV><STRONG>Nervous System Effects<BR></STRONG>Headache </IMG>is the most
frequent adverse nervous system effect of statins, occurring in about 2–17% of
patients receiving the drugs in controlled clinical trials.<A
onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L1R158&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>Asthenia,<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L1R168&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>fatigue,<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L1R177&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>and dizziness<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L1R191&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>occurred in about 1–4% of patients receiving statin therapy
in controlled clinical trials.<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L2R31&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>Dysfunction of certain cranial nerves<A
onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L2R69&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>(including alteration of taste,<A
onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L2R101&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>impairment of extraocular movement,<A
onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L2R137&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>and facial paresis),<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L2R158&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>tremor,<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L2R166&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>hypertonia,<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L2R178&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>vertigo,<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L2R187&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>memory impairment or loss,<A
onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L2R214&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>paresthesia,<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L2R227&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>peripheral neuropathy,<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L2R250&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A> peripheral nerve palsy<STRONG>,</STRONG><A
onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L3R24&DrugCode=1-6312"
target=page><STRONG><FONT color=#000000><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></FONT></STRONG></A><STRONG>anxiety,</STRONG><A
onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L3R33&DrugCode=1-6312"
target=page><STRONG><FONT color=#000000><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></FONT></STRONG></A><STRONG>insomnia,</STRONG><A
onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L3R43&DrugCode=1-6312"
target=page><STRONG><FONT color=#000000><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></FONT></STRONG></A><STRONG>somnolence</STRONG>,<A
onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L3R55&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>and depression<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L3R70&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>also have been reported with statin therapy. Psychic
disturbances,<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L3R137&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>sleep disturbances,<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L3R157&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>abnormal dreams,<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L3R174&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>orticollis,<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L3R186&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>hypesthesia,<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L3R199&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>hyperkinesia,<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L3R213&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>incoordination,<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L3R229&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>paralysis,<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L3R240&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>neck rigidity,<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L4R5&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>migraine,<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L4R15&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>emotional lability,<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L4R35&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>and amnesia<A onclick="resizeWin('page',300,300)"
href="http://www.medscape.com/px/DrugSearch?refIDS=0S2177161B177162L4R47&DrugCode=1-6312"
target=page><IMG height=15
src="http://images.medscape.com/pi/features/drugdirectory/page.gif" width=12
border=0></IMG></A>have been reported with at least one statin.<BR></DIV>
<BLOCKQUOTE
style="PADDING-RIGHT: 0px; PADDING-LEFT: 5px; MARGIN-LEFT: 5px; BORDER-LEFT: #000000 2px solid; MARGIN-RIGHT: 0px">
<DIV style="FONT: 10pt arial">----- Original Message ----- </DIV>
<DIV
style="BACKGROUND: #e4e4e4; FONT: 10pt arial; font-color: black"><B>From:</B>
<A title=c09626@cofas.es href="mailto:c09626@cofas.es">M. Jose Cachafeiro</A>
</DIV>
<DIV style="FONT: 10pt arial"><B>To:</B> <A title=af@listas.uninet.edu
href="mailto:af@listas.uninet.edu">Lista de correo de Atención
Farmacéutica</A> </DIV>
<DIV style="FONT: 10pt arial"><B>Sent:</B> Friday, September 05, 2003 1:03
PM</DIV>
<DIV style="FONT: 10pt arial"><B>Subject:</B> RE: [AF] zocor-sueño</DIV>
<DIV><BR></DIV>
<DIV><FONT face=Arial size=2>En el boletin de informacion farmacoterapeutica
de Navarra he encontrado lo siguiente:</FONT></DIV>
<DIV> </DIV>
<DIV><FONT face=Arial size=2><B>"Otros:</B> Las reacciones de
hipersensibilidad que cursan con artralgia y trombocitopenia suelen ser
excepcionales. La simvastatina y lovastatina pueden de forma ocasional,
potenciar el efecto de los anticoagulantes orales. Los IHMGCoAr no tienen un
efecto significativo sobre la litogenicidad de la bilis. <STRONG>El hecho de
que la pravastatina sea un fármaco hidrofílico, mientras que los otros dos
tengan un marcado carácter lipofílico, puede explicar la menor incidencia en
el primero de efectos secundarios relacionados con el SNC, sobre todo en lo
relativo a la capacidad de atención o a los patrones de sueño</STRONG>."
</FONT></DIV>
<DIV> </DIV>
<DIV><FONT face=Arial size=2>Es una revision de diciembre de 1994.</FONT><FONT
face=Arial size=2> Lo tienes completo en la siguiente direccion: <A
href="http://www.cfnavarra.es/WebGN/SOU/publicac/bj/textos/v2n5.htm">http://www.cfnavarra.es/WebGN/SOU/publicac/bj/textos/v2n5.htm</A></FONT></DIV>
<DIV> </DIV>
<DIV><FONT face=Arial size=2>La base de datos del Consejo tambien incluye como
efecto secundario raro (<1%) del zocor insomnio.</FONT></DIV>
<DIV><FONT face=Arial size=2></FONT> </DIV>
<DIV><FONT face=Arial size=2>Saludos:</FONT></DIV>
<DIV> </DIV>
<DIV><FONT face=Arial size=2>Mª José Cachafeiro</FONT></DIV>
<DIV><FONT face=Arial size=2>Farmaceutica - Asturias</FONT></DIV>
<BLOCKQUOTE
style="PADDING-RIGHT: 0px; PADDING-LEFT: 5px; MARGIN-LEFT: 5px; BORDER-LEFT: #000000 2px solid; MARGIN-RIGHT: 0px">
<DIV style="FONT: 10pt arial">----- Original Message ----- </DIV>
<DIV
style="BACKGROUND: #e4e4e4; FONT: 10pt arial; font-color: black"><B>From:</B>
<A title=m.claveria.001@recol.es href="mailto:m.claveria.001@recol.es">Fcia.
Clavería</A> </DIV>
<DIV style="FONT: 10pt arial"><B>To:</B> <A title=af@listas.uninet.edu
href="mailto:af@listas.uninet.edu">Lista de correo de Atención
Farmacéutica</A> </DIV>
<DIV style="FONT: 10pt arial"><B>Sent:</B> Thursday, September 04, 2003 7:08
PM</DIV>
<DIV style="FONT: 10pt arial"><B>Subject:</B> [AF] zocor-sueño</DIV>
<DIV><BR></DIV>
<DIV><FONT face=Arial size=2>hola compañeros:</FONT></DIV>
<DIV><FONT face=Arial size=2> tengo un paciente que empezo a tomar
zocor 10 mg ( simvastatina ), una pastilla diaria por la noche, y
noto una disminuición de su calidad de sueño. Ahora le han
cambiado a 20 mg y comenta que duerme peor. No toma ninguna medicacion
más, o al menos eso afirma. Yo he buscado por si hubiese alguna
relación pero no he encontrado nada ¿alguien me puede dar una pista?
</FONT></DIV>
<DIV><FONT face=Arial size=2>muchas gracias por adelantado.</FONT></DIV>
<DIV><FONT face=Arial size=2>Isabel Claveria, Zaragoza</FONT></DIV>
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