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<BODY>
<P> Personalmente utilizo el método de Naranjo. En el Centro de Farmacovigilancia de la Comunidad Valenciana utilizan otro método algo más sofisticado que adjunto a continuación:</P>
<P><BR></P>
<P>ALGORITMO DEL CENTRO NACIONAL DE FARMACOVIGILANCIA</P>
<P><BR></P>
<P>Valores mínimos y máximos para cada una de las cuestiones planteadas</P>
<DIV><TABLE border=1 style='{border-width : 0px}' cellpadding=0 bordercolor="#000000" cellspacing=-1 style='{border-collapse: collapse;}'>
<TR valign=top>
<TD width=178 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>CUESTIONES</P>
</TD>
<TD width=101 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>V. mínimo</P>
</TD>
<TD width=98 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>V. máximo</P>
</TD>
</TR>
<TR valign=top>
<TD width=178 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Secuencia temporal</P>
</TD>
<TD width=101 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>-2</P>
</TD>
<TD width=98 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>+2</P>
</TD>
</TR>
<TR valign=top>
<TD width=178 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Conocimiento previo</P>
</TD>
<TD width=101 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>-1</P>
</TD>
<TD width=98 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>+2</P>
</TD>
</TR>
<TR valign=top>
<TD width=178 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Efecto retirada</P>
</TD>
<TD width=101 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>-2</P>
</TD>
<TD width=98 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>+2</P>
</TD>
</TR>
<TR valign=top>
<TD width=178 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Reexposición</P>
</TD>
<TD width=101 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>-1</P>
</TD>
<TD width=98 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>+3</P>
</TD>
</TR>
<TR valign=top>
<TD width=178 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Causas alternativas</P>
</TD>
<TD width=101 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>-3</P>
</TD>
<TD width=98 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>+1</P>
</TD>
</TR>
<TR valign=top>
<TD width=178 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Factores contribuyentes </P>
</TD>
<TD width=101 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>0</P>
</TD>
<TD width=98 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>+1</P>
</TD>
</TR>
<TR valign=top>
<TD width=178 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Exploraciones</P>
</TD>
<TD width=101 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>0</P>
</TD>
<TD width=98 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>+1</P>
</TD>
</TR>
</TABLE>
</DIV>
<P class=RVPS1><BR></P>
<DIV><TABLE border=1 style='{border-width : 0px}' cellpadding=0 bordercolor="#000000" cellspacing=-1 style='{border-collapse: collapse;}'>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1><SPAN class=RVTS2>SECUENCIA TEMPORAL</SPAN></P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>Puntuación</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Compatible</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>+2</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Compatible no coherente</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>+1</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>No hay información</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>0</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Incompatible</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>-1</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>RAM al retirar</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>-2</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1><SPAN class=RVTS2>CONOCIMIENTO PREVIO</SPAN></P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1><BR></P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Conocida</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>+2</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Referencias ocasionales</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>+1</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Desconocida</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>0</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Información en contra</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>-1</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1><SPAN class=RVTS2>EFECTO RETIRADA</SPAN></P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1><BR></P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Retirado y mejora</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>+2</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Retirado y no mejora</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>-2</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>No retirado y no mejora</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>+1</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>No retirado y mejora</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>-2</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Sin datos</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>0</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Mortal/Irreversible</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>0</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Mejora por tolerancia</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>+1</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Mejora por tratamiento</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>+1</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1><SPAN class=RVTS2>REEXPOSICIÓN</SPAN></P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1><BR></P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Positiva: aparece la RAM</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>+3</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Negativa: no aparece la RAM</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>-1</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>No hay reexposición</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>0</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Mortal/Irreversible</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>0</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Reacción previa similar con otra especialidad</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>+1</P>
</TD>
</TR>
<TR valign=top>
<TD width=321 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Reacción similar con otro fármaco</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>+1</P>
</TD>
</TR>
</TABLE>
</DIV>
<P class=RVPS1><BR></P>
<DIV><TABLE border=1 style='{border-width : 0px}' cellpadding=0 bordercolor="#000000" cellspacing=-1 style='{border-collapse: collapse;}'>
<TR valign=top>
<TD width=122 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1><SPAN class=RVTS2>PROBABILIDAD</SPAN></P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1><SPAN class=RVTS2>PUNTUACIÓN</SPAN></P>
</TD>
<TD width=190 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1><SPAN class=RVTS2>VALORACIÓN</SPAN></P>
</TD>
</TR>
<TR valign=top>
<TD width=122 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Definida</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>>8</P>
</TD>
<TD width=190 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Relación casual asumible</P>
</TD>
</TR>
<TR valign=top>
<TD width=122 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Probable</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>6-7</P>
</TD>
<TD width=190 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Relación casual asumible</P>
</TD>
</TR>
<TR valign=top>
<TD width=122 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Posible</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>4-5</P>
</TD>
<TD width=190 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Conexión dudosa</P>
</TD>
</TR>
<TR valign=top>
<TD width=122 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Condicional</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>1-3</P>
</TD>
<TD width=190 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>No se puede valorar</P>
</TD>
</TR>
<TR valign=top>
<TD width=122 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>Improbable</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1><0</P>
</TD>
<TD width=190 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>No se puede valorar</P>
</TD>
</TR>
<TR valign=top>
<TD width=122 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>No clasificada</P>
</TD>
<TD width=95 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P class=RVPS1>Sin datos</P>
</TD>
<TD width=190 valign=top style='{border-width : 1px; border-color : #000000; border-style: solid; }'>
<P>No se puede valorar</P>
</TD>
</TR>
</TABLE>
</DIV>
<P class=RVPS1><BR></P>
<P>Saludos.</P>
<P>Francisco García Cebrian</P>
<P>Valencia</P>
<P>Nos vemos en el congreso de..............</P>
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