[AF] Crisarobina

[Isabela]

Hola:
Espero te sirva.
                                Isabela Justo
                                Sevilla


Mira en la página de acofarma: http://www.acofarma.com/pdf/htm/c139.htm
En Merck Index:
        Monograph Number:  0000768
Title:  Araroba
CAS Registry Number:  1393-64-2
Additional Names:  Goa powder;  crude chrysarobin;  Brazil powder;  ringworm
powder;  “Arariba”
Literature References:  Found in cavities in the trunk of Andira araroba,
Aguiar (Vouacapoua araroba [Aguiar] Lyons), Leguminosae and freed as much as
possible from fragments of wood.  Habit.  In damp forests of Brazil and
Bahia.  Constit.  About 50% chrysarobin; chrysophanic acid, gum, about 2%
resin, ararobinol¾said to be the methyl ether of emodin.
Properties:  Brown-yellow, slightly cryst, rough, odorless powder; becomes
brownish on exposure to air.
Therap-Cat:  Dermatologic.
        
        Monograph Number:  0002253
Title:  Chrysarobin
CAS Registry Number:  491-59-8
Additional Names:  Purified Goa powder;  purified araroba
Literature References:  Improperly called “medicinal chrysophanic acid”.
The name chrysarobin today has two meanings:  (1) A commercial product
consisting of 70-85% of different anthraquinone derivs extracted from Goa
powder (Araroba); (2) A pure substance, (1,8-dihydroxy-3-methyl-9-anthrone;
3-methyl-1,8,9-anthracenetriol), reduction product of chrysophanic acid,
q.v.  This pure substance constitutes about 30% of commercial chrysarobin.
Isoln of the commercial product from the wood of Andira araroba Aguiar
[Vouacapoua araroba (Aguiar) Lyons], Leguminosae:  Liebermann, Siedler, Ann.
212, 29 (1882); Hesse; ibid. 309, 53 (1899).  Prepn of the pure substance by
reduction of chrysophanic acid:  Naylor, Gardner, J. Am. Chem. Soc. 53, 4114
(1931).
Properties:  Commercial product, brownish to orange-yellow,
microcrystalline, odorless, tasteless powder.  Irritating to mucous
membranes; causes dangerous inflammation if it enters the eye.  Very
slightly sol in water; 1 g dissolves in 385 ml alcohol, 30 ml benzene, 15 ml
chloroform, 160 ml ether, 180 ml carbon disulfide; also sol in fats.
Dissolves in alkali hydroxides or in H2SO4 with a red color and is pptd from
the H2SO4 soln by diluting with H2O.

Derivative Type:  Pure substance 
CAS Registry Number:  491-58-7
Molecular Formula:  C15H12O3
Molecular Weight:  240.25
Percent Composition:  C 74.99%, H 5.03%, O 19.98%
Properties:  Yellow needles from glacial acetic acid, mp 203.4-204°.
Melting point:  mp 203.4-204°

CAUTION:  Ingestion may cause renal damage, severe gastroenteritis.
Application to large areas of skin may cause renal irritation by
percutaneous absorption.  Inadvertent conjunctival contact frequently
produces conjunctivitis.  Allergic reaction of skin has been reported.
Therap-Cat:  Has been used as antipsoriatic.
Therap-Cat-Vet:  Has been used in ringworm, and noninfectious diseases of
the skin.
Keywords:  Antipsoriatic.