[AF] Retirada de Seropram y metrorragia

[mmadurga en agemed.es]

Estimada Teresa:
No tengo a mano copia del artículo que publicamos en 2006 sobre ISRS y HDA a partir de la situación, con riesgo en el caso de tto combinados con AINE y AAS (http://www.ncbi.nlm.nih.gov/pubmed/16611206?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
 
de Abajo FJ <https://portal.msc.es/sites/entrez?Db=pubmed&Cmd=Search&Term=%22de%20Abajo%20FJ%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus> , Montero D <https://portal.msc.es/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Montero%20D%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus> , Rodríguez LA <https://portal.msc.es/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Rodr%C3%ADguez%20LA%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus> , Madurga M <https://portal.msc.es/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Madurga%20M%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus> .Antidepressants and risk of upper gastrointestinal bleeding. Basic Clin Pharmacol Toxicol. <javascript:AL_get(this, 'jour', 'Basic Clin Pharmacol Toxicol.');>  2006 Mar;98(3):304-10.
Division of Pharmacoepidemiology and Pharmacovigilance, Spanish Agency for Medicines and Healthcare Products, Madrid, Spain. fabajo en agemed.es

Selective serotonin reuptake inhibitors (SSRIs) are nowadays the most widely used antidepressants in the world, mainly because they have a better adverse reaction profile and a higher safety margin in overdoses, when compared to other antidepressants. These drugs recently have been the target of important debates concerning safety issues, among them the possibility that they may increase the risk of bleeding. Over the 1990s, an increasing number of individual cases of bleeding disorders were reported in the literature and to the pharmacovigilance programmes which prompted several epidemiological and pharmacological studies. In this review we have examined all available data. The whole evidence supports the hypothesis that antidepressants with a relevant blockade action on serotonin reuptake mechanism increase the risk of bleeding. Such disorders may have different degrees of severity and may be located anywhere in the body. The epidemiological evidence is, however, more robust for upper gastrointestinal bleeding. It has been estimated that upper gastrointestinal bleeding may occur at a frequency ranging from 1 in 100 to 1 in 1,000 patient-years of exposure to high-affinity drugs (the SSRIs), with the very old patients being in the highest part of the range. The increased risk may be of particular relevance when the SSRIs are associated with NSAIDs as well as low-dose aspirin.

Cuando vuelva a España os facilito el artículo completo. Hay posteriores publicados sobre HDA y los ISRS que habrá que revisar, aunque con metrorragia solo aparece en Medline el que comenta Ramón.
Un abrazo,
Mariano