[AF] Interacciones del Fluconazol (cont)

Mariano Madurga mmadurgasanz en gmail.com
Sab Mar 10 10:01:20 CET 2012

Hola Sonia:Si te manejas con el inglés, te puedo recomendar esta página web: 
 chequea las posibles interacciones entre medicamentos que se van tecleando los nombres: valproic + olanzapine + fluconazole y al activar, responde con las interacciones identificadas, ver: http://www.drugs.com/interactions-check.php?drug_list=1096-0,1744-0,2286-0

Te copio el texto:

 Interactions between your selected drugs

 valproic acid ↔ olanzapine

Applies to: valproic acid, olanzapine

 MONITOR: Concurrent use of olanzapine and valproic acid may potentiate the risk of hepatotoxicity. The exact mechanism of interaction is unknown. In a retrospective study of 52 children, combined treatment with olanzapine and divalproex was associated with more frequent elevations of hepatic enzymes than either agent alone, and mean and peak hepatic enzyme levels during the observed course of treatment were also higher. All 12 patients who received combined treatment had at least one peak enzyme elevation above the normal range, versus 10 of 17 who received olanzapine alone and 6 of 23 who received divalproex alone. With the exception of 2 patients who required discontinuation of combination treatment (due to development of pancreatitis in one and steatohepatitis in the other), the observed peak and mean enzyme levels were less than 3 times the upper limit of normal (ULN) and were asymptomatic. The long-term significance of these findings is unknown.
MANAGEMENT: The authors of the study recommend monitoring liver function tests every 3 to 4 months during the first year of treatment with either olanzapine or valproic acid, at least in pediatric patients. If no elevations of liver enzymes or marked weight gain occur after one year, a decrease in frequency of monitoring to every 6 months can be considered. Patients should be advised to notify their physician if they experience signs and symptoms of hepatotoxicity such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, and jaundice.
 No other interactions were found between your selected drugs.
Note: this does not necessarily mean no interactions exist. ALWAYS consult with your doctor or pharmacist.
 Other drugs that your selected drugs interact with

 fluconazole interacts with more than 300 other drugs. olanzapine interacts with more than 400 other drugs. valproic acid interacts with more than 200 other drugs. 

 Interactions between your selected drugs and food

 No results found - however, this does not necessarily mean no interactions exist. ALWAYS consult with your doctor or pharmacist.


Un abrazo,

Mariano Madurga

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