[AF] Nuevo palo para la Equinacea
Ramon Diaz-Alersi
rda en uninet.edu
Vie Jul 29 22:08:52 CEST 2005
http://content.nejm.org/cgi/content/short/353/4/341:
N Engl J Med. 2005 Jul 28;353(4):341-8. An evaluation of Echinacea
angustifolia in experimental rhinovirus infections. Turner RB, Bauer R,
Woelkart K, Hulsey TC, Gangemi JD. University of Virginia School of
Medicine, Charlottesville, VA 22908, USA. rbt2n en virginia.edu
BACKGROUND: Echinacea has been widely used as an herbal remedy for the
common cold, but efficacy studies have produced conflicting results, and
there are a variety of echinacea products on the market with different
phytochemical compositions. We evaluated the effect of chemically
defined extracts from Echinacea angustifolia roots on rhinovirus
infection. METHODS: Three preparations of echinacea, with distinct
phytochemical profiles, were produced by extraction from E. angustifolia
roots with supercritical carbon dioxide, 60 percent ethanol, or 20
percent ethanol. A total of 437 volunteers were randomly assigned to
receive either prophylaxis (beginning seven days before the virus
challenge) or treatment (beginning at the time of the challenge) either
with one of these preparations or with placebo. The results for 399
volunteers who were challenged with rhinovirus type 39 and observed in a
sequestered setting for five days were included in the data analysis.
RESULTS: There were no statistically significant effects of the three
echinacea extracts on rates of infection or severity of symptoms.
Similarly, there were no significant effects of treatment on the volume
of nasal secretions, on polymorphonuclear leukocyte or interleukin-8
concentrations in nasal-lavage specimens, or on quantitative-virus
titer. CONCLUSIONS: The results of this study indicate that extracts of
E. angustifolia root, either alone or in combination, do not have
clinically significant effects on infection with a rhinovirus or on the
clinical illness that results from it. Copyright 2005 Massachusetts
Medical Society.
Felices vacaciones para los que las empiecen y paciencia a los demás...
--
Ramón Díaz-Alersi
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