Re: [AF] Citalopram y inflamación del nervio óptico

Olaf Dominguez odomingu en
Mie Ene 18 20:28:55 CET 2006

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Lehman NL. Johnson LN.
Institution Neuro-ophthalmology Unit, Mason Eye Institute, University of Missouri-Columbia, USA.
Title Toxic optic neuropathy after concomitant use of melatonin, zoloft, and a high-protein diet.
Source Journal of Neuro-Ophthalmology. 19(4):232-4, 1999 Dec.
Local Messages On Shelves At: GenHosp(partial).
Abstract Melatonin is a neuromodulating hormone found in the pineal gland and retina. It is involved in light-dark circadian rhythms and mediates retinal processes in a manner antagonistic to that of dopamine. Zoloft (sertraline) is an antidepressant drug that blocks the reuptake of serotonin at the neural synapse. Serotonin is the natural precursor of melatonin. A 42-year-old woman sought treatment for visual acuity loss, dyschromatopsia, and altered light adaptation. Neuro-ophthalmologic examination was otherwise normal except for evolving bilateral cecocentral scotomas. She had taken Zoloft for 4 years and began a high-protein diet with melatonin supplementation 2 weeks before onset of visual symptoms. Visual acuity and color vision improved within 2 months after melatonin and the high-protein diet were discontinued. Combined use of melatonin, Zoloft, and a high-protein diet may have resulted in melatonin/dopamine imbalance in the retina, manifesting as a toxic optic neur
opathy. Physicians and patients should be alerted to this potential drug interaction.
Quizas sea le momento para reportar el caso.

Olaf Dominguez

----- Original Message -----
From: Anna
Date: Wednesday, January 18, 2006 10:33 am
Subject: [AF] Citalopram y inflamación del nervio óptico
To: AF en

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