[AF] COLAGENOS v.o.

[Afcofsevilla]

Nutr J. <https://www.ncbi.nlm.nih.gov/pubmed/26822714>  2016 Jan
29;15:14. doi: 10.1186/s12937-016-0130-8.

Efficacy and tolerability of an undenatured type II collagen supplement
in modulating knee osteoarthritis symptoms: a multicenter randomized,
double-blind, placebo-controlled study.

Lugo JP
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Lugo%20JP%5BAuthor%5D&cauthor
=true&cauthor_uid=26822714> 1, Saiyed ZM
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Saiyed%20ZM%5BAuthor%5D&cauth
or=true&cauthor_uid=26822714> 2, Lane NE
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Lane%20NE%5BAuthor%5D&cauthor
=true&cauthor_uid=26822714> 3.

Author information <https://www.ncbi.nlm.nih.gov/pubmed/26822714> 

Abstract

BACKGROUND:

Undenatured type II collagen (UC-II) is a nutritional supplement derived
from chicken sternum cartilage. The purpose of this study was to
evaluate the efficacy and tolerability of UC-II for knee osteoarthritis
(OA) pain and associated symptoms compared to placebo and to glucosamine
hydrochloride plus chondroitin sulfate (GC).

METHODS:

One hundred ninety one volunteers were randomized into three groups
receiving a daily dose of UC-II (40 mg), GC (1500 mg G & 1200 mg C), or
placebo for a 180-day period. The primary endpoint was the change in
total Western Ontario McMaster Universities Osteoarthritis Index (WOMAC)
from baseline through day 180 for the UC-II group versus placebo and GC.
Secondary endpoints included the Lequesne Functional Index (LFI), the
Visual Analog Scale (VAS) for pain and the WOMAC subscales. Modified
intent-to-treat analysis were performed for all endpoints using analysis
of covariance and mixed model repeated measures, while incremental area
under the curve was calculated by the intent-to-treat method.

RESULTS:

At day 180, the UC-II group demonstrated a significant reduction in
overall WOMAC score compared to placebo (p = 0.002) and GC (p = 0.04).
Supplementation with UC-II also resulted in significant changes for all
three WOMAC subscales: pain (p = 0.0003 vs. placebo; p = 0.016 vs. GC);
stiffness (p = 0.004 vs. placebo; p = 0.044 vs. GC); physical function
(p = 0.007 vs. placebo). Safety outcomes did not differ among the
groups.

CONCLUSION:

UC-II improved knee joint symptoms in knee OA subjects and was
well-tolerated. Additional studies that elucidate the mechanism for this
supplement's actions are warranted.

 

 

Nutr Hosp. <https://www.ncbi.nlm.nih.gov/pubmed/26267777>  2015 Jul
18;32 Suppl 1:62-6. doi: 10.3305/nh.2015.32.sup1.9482.

[An overview of the beneficial effects of hydrolysed collagen intake on
joint and bone health and on skin ageing].

[Article in Spanish; Abstract available in Spanish from the publisher]

Figueres Juher T
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Figueres%20Juher%20T%5BAuthor
%5D&cauthor=true&cauthor_uid=26267777> 1, Basés Pérez E
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Bas%C3%A9s%20P%C3%A9rez%20E%5
BAuthor%5D&cauthor=true&cauthor_uid=26267777> 2.

Author information <https://www.ncbi.nlm.nih.gov/pubmed/26267777> 

Abstract

in English <https://www.ncbi.nlm.nih.gov/pubmed/26267777> , Spanish
<https://www.ncbi.nlm.nih.gov/pubmed/26267777> 

INTRODUCTION:

Hydrolysate Collagen (HC) consists of small peptides with a molecular
weight lower than 5.000 Da. produced from gelatinization and subsequent
enzymatic hydrolysis of native collagen which is found in rich
collagenic animal tissues. There is much evidence about the HC ingestion
positive effect over degenerative joint and bones diseases.

OBJECTIVE:

The aim of this article is to review the present scientific studies
about HC and to evaluate the HC ingestion therapeutical effects on some
collagenic tissues as cartilage, bones and skin.

RESULTS:

Up to date, there are more than 60 scientific studies (in vitro, in
vivo, clinics and on bioavailability) about HC ingestion efficacy on
reducing collagen damage and loss consequences as joint pain and erosion
(osteoarthritis), bone density loss (osteoporosis) and skin ageing.

CONCLUSIONS:

Preclinical studies show that HC stimulates collagenic tissue
regeneration by increasing not only collagen synthesis but minor
components (glycosaminoglycans and hyaluronic acid) synthesis as well.
Clinical studies show that HC continual ingestion helps to reduce and
prevent joint pain, bone density loss and skin ageing. These results as
well as its high level of tolerance and safety make HC ingestion
attractive for a long-term use in bone and joint degenerative diseases
and in fight against skin ageing.

 

 

 

Int J Food Sci Nutr. <https://www.ncbi.nlm.nih.gov/pubmed/19212858>
2009;60 Suppl 2:99-113. doi: 10.1080/09637480802498820. Epub 2009 Feb
11.

A randomized controlled trial on the efficacy and safety of a food
ingredient, collagen hydrolysate, for improving joint comfort.

Benito-Ruiz P
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Benito-Ruiz%20P%5BAuthor%5D&c
author=true&cauthor_uid=19212858> 1, Camacho-Zambrano MM
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Camacho-Zambrano%20MM%5BAutho
r%5D&cauthor=true&cauthor_uid=19212858> , Carrillo-Arcentales JN
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Carrillo-Arcentales%20JN%5BAu
thor%5D&cauthor=true&cauthor_uid=19212858> , Mestanza-Peralta MA
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Mestanza-Peralta%20MA%5BAutho
r%5D&cauthor=true&cauthor_uid=19212858> , Vallejo-Flores CA
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Vallejo-Flores%20CA%5BAuthor%
5D&cauthor=true&cauthor_uid=19212858> , Vargas-López SV
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Vargas-L%C3%B3pez%20SV%5BAuth
or%5D&cauthor=true&cauthor_uid=19212858> , Villacís-Tamayo RA
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Villac%C3%ADs-Tamayo%20RA%5BA
uthor%5D&cauthor=true&cauthor_uid=19212858> , Zurita-Gavilanes LA
<https://www.ncbi.nlm.nih.gov/pubmed/?term=Zurita-Gavilanes%20LA%5BAutho
r%5D&cauthor=true&cauthor_uid=19212858> .

Author information <https://www.ncbi.nlm.nih.gov/pubmed/19212858> 

Abstract

INTRODUCTION:

Current options to promote joint comfort are limited to medicines that
can reduce pain but can also have adverse effects. Collagen, a major
component of joint cartilage, is found in the diet, particularly in
meat. Its hydrolysed form, collagen hydrolysate (CH), is well absorbed.
CH may stimulate the joint matrix cells to synthesize collagen, so
helping to maintain the structure of the joint and potentially to aid
joint comfort.

METHODS:

In a randomized, double-blind, controlled multicentre trial, 250
subjects with primary osteoarthritis of the knee were given 10 g CH
daily for 6 months.

RESULTS:

There was a significant improvement in knee joint comfort as assessed by
visual analogue scales to assess pain and the Womac pain subscale.
Subjects with the greatest joint deterioration, and with least intake of
meat protein in their habitual diets, benefited most.

CONCLUSION:

CH is safe and effective and warrants further consideration as a food
ingredient.

 

Saludos.

Rosario Cáceres Fernández-Bolaños  

Centro de Información del Medicamento y Atención Farmacéutica

afcofsevilla en redfarma.org <mailto:cimse en redfarma.org> 

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